Incorporation of a guanidine functional group into the PNA backbone facilitates cellular uptake of PNA into mammalian cells with efficiency comparable to that of the TAT transduction domain The modified PNA recognizes and binds to the complementary DNA strand in accordance with Watson−Crick recognition rules However, unlike polypyrimidine PNA which binds to DNA in 21Ian A Cliffe, in Comprehensive Organic Functional Group Transformations, 1995 (iii) NAcyliminocarbonyl derivatives from guanidines Unsubstituted and monosubstituted guanidines are acylated by condensation of the requisite guanidine free base with the appropriate acid ester < 61CJC1017, 75AF1477 > The preparation of diand trisubstituted guanidines takes longer and inTurner Construction Company Aug 13 Jun 151 year 11 months Dallas/Fort Worth Area Project Hall Arts Center Downtown Dallas ($72 million)
Selective Functional Group Transformation Using Guanidine The Conversion Of An Ester Group Into An Amide In Vinylogous Ester Aldehydes Of Imidazole Sciencedirect
